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"Very fast and convenient. I first messaged Chris at 10:08am and I was picking up my prescriptions from the pharmacy at 10:52am same day! Cannot recommend enough!!!!"

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Cellulitis & Impetigo Guide

Skin Infection: What You Need to Know

Complete guide to treatment, home care, and when to seek emergency help after your NPCWoods visit

Text Us for Questions
Reviewed by Chris Woods, MSN, APRN, FNP-C — Licensed Nurse Practitioner. Updated March 2026.

What Is a Skin Infection?

Your skin is your body's first line of defense. When bacteria get through a break in your skin — a cut, scrape, bug bite, or even cracked dry skin — they can multiply quickly. Skin infections come in different forms, and understanding which one you have helps you know what to expect during treatment.

Cellulitis

Infection of the deeper skin layers (dermis). Shows as spreading redness, warmth, swelling, and tenderness. Often comes with fever and is more serious than surface infections.

Impetigo

Surface-level infection (epidermis). Shows as honey-colored crusted sores or fluid-filled blisters. More common in kids but can affect anyone. Highly contagious.

Abscess

A pocket of pus trapped under the skin. Feels like a bump or nodule with a soft, fluctuant center. Needs drainage and antibiotics to fully resolve.

Recognize the Symptoms

Skin infection symptoms vary depending on the type and how deep the infection is. Here's what to look for:

Cellulitis Signs
  • Red, swollen area that's warm to touch
  • Redness that spreads outward
  • Pain or tenderness
  • Fever (often 101°F or higher)
  • Red streaks extending from the area (lymphangitis)
Impetigo Signs
  • Honey-colored crusty sores
  • Red sores that ooze then crust over
  • Usually around nose, mouth, or other exposed areas
  • Itchy but not usually painful
  • May or may not have fever
Mark the border: Use a pen to draw a line around the red area. Check it every few hours. If the redness spreads past your mark, the infection is advancing and you need immediate care.

Your Antibiotics: What to Expect

Antibiotics are the main treatment. You'll be prescribed one of these based on your infection type and any MRSA risk:

Cephalexin (Keflex)
First-line for cellulitis — very effective for most cases
How It Works
Kills bacteria by disrupting their cell walls. Works quickly.
Typical Dose
500 mg four times daily for 7–10 days
Side Effects
Nausea, diarrhea (usually mild). Take with food.
Doxycycline
Used for MRSA or cephalosporin allergy
How It Works
Antibiotic that covers both common and resistant bacteria.
Typical Dose
100 mg twice daily for 7–10 days
Side Effects
Photosensitivity (sun sensitivity). Use sunscreen daily.
Mupirocin (Bactroban)
Topical antibiotic for impetigo
How It Works
Applied directly to the sores. Kills bacteria at the source.
Application
Small amount to affected area 2–3 times daily. Cover with clean gauze.
Duration
7–10 days. Often combined with oral antibiotics.
Finish your full course. Even if the infection looks better in 2–3 days, take every single dose for the full 7–10 days. Stopping early can let bacteria bounce back — sometimes stronger — and risk complications.
Watch for These Red Flags

These signs mean the infection is getting worse. Contact us immediately or seek emergency care:

  • Red streaks extending from the infected area toward your heart (lymphangitis)
  • Redness spreading rapidly (beyond your pen-marked border within hours)
  • High fever (103°F or higher) or fever not responding to medication
  • Infection near your eye, face, or on your hand (risk of serious spread)
  • Signs of an abscess forming (soft, fluctuant center; increasing pus)
  • Not improving at all after 48 hours on antibiotics
  • Increasing pain despite pain medication
  • Swollen lymph nodes near the infection (in groin, armpit, or neck)

Home Care: Help Your Body Heal

While antibiotics do the bacterial killing, your job is to support your immune system, prevent spread, and manage comfort:

Keep Area Clean & Dry

Wash gently with soap and water 2–3 times daily. Pat dry (don't rub). Cover with a clean bandage to prevent spread.

Warm Compress for Cellulitis

Apply a clean, warm (not hot) compress for 15 minutes, 3–4 times daily. Increases blood flow and comfort.

Elevate the Affected Limb

If on your leg or arm, elevate above heart level when sitting or lying down. Reduces swelling and improves circulation.

Don't Squeeze or Pop

Resist the urge to pop blisters or drain pus. This spreads bacteria and increases contagion. Let antibiotics do the work.

Keep Wound Covered

Use a fresh, clean bandage daily (or more if it gets wet/dirty). Change after showering. Prevents contamination and spread.

Hand Hygiene First

Wash hands thoroughly before and after touching the infected area. Prevents spreading to other body parts or other people.

Don't Share Personal Items

Use your own towels, razors, and washcloths. Don't share bed linens. This prevents spreading to family members.

Prevent Future Skin Infections

Once you've had a skin infection, your skin is more vulnerable. Here's how to reduce your risk:

Clean Cuts & Scrapes Immediately

Wash with soap and water right away. Apply antibiotic ointment and cover. Don't let them sit uncleaned.

Keep Skin Moisturized

Dry, cracked skin is an entry point for bacteria. Use a good moisturizer, especially in winter or dry climates.

Watch Those Bug Bites

If a bite looks red, swollen, or starts oozing, don't wait — that's an infection starting. Treat immediately.

Practice Good Wound Care

For any break in skin: clean, antibiotic ointment, cover. Check it daily. If it gets worse, don't wait.

Is My Infection Contagious?

Contagiousness depends on the type of infection and whether it's draining:

Impetigo
Very contagious, especially in kids. The fluid in blisters and under crusts contains bacteria. Highly likely to spread to others through direct contact or shared items. After 24–48 hours on antibiotics, contagion drops significantly.
Cellulitis (No Open Sore)
Generally NOT contagious unless the skin is broken or draining. If there's no open wound, bacteria aren't escaping to infect others.
Cellulitis (With Drainage)
Contagious. The pus contains bacteria. Cover it, keep it clean, and practice hand hygiene religiously.
After 24 Hours on Antibiotics
Contagion risk drops dramatically. By this point, bacterial load is decreasing and spread is less likely. You're safe to be around others if you keep the area covered and practice good hygiene.

Frequently Asked Questions

Impetigo is very contagious, especially in kids. Cellulitis is usually not contagious unless you have open, draining wounds. Either way, keep the area clean and covered, practice good hand hygiene, and don't share towels or razors. After 24 hours on antibiotics, contagion risk drops significantly.

No. Do not squeeze, pop, or drain the infection yourself. This spreads bacteria and increases contagion risk. Keep it clean and covered instead. Let antibiotics do the work. If you're concerned about an abscess or heavy drainage, text us — we can advise or arrange proper drainage.

MRSA (methicillin-resistant Staph aureus) looks like any other skin infection — red, swollen, sometimes with a pustule or small abscess. The only way to know for sure is a culture, which your provider may have done or ordered. If standard antibiotics aren't working after 48 hours, we may switch to MRSA-coverage antibiotics like doxycycline.

Yes, skin infections can recur, especially if you don't finish antibiotics, reinfect the same area, or have repeated breaks in your skin (cuts, bug bites, dry cracks). Complete your full antibiotic course, keep skin moisturized, practice wound care, and avoid close contact with towels, razors, or other people during treatment.

Most people see improvement in redness within 48–72 hours of starting antibiotics. However, complete clearing can take 1–2 weeks. The redness fades as inflammation decreases. Mark the border with a pen — if the redness spreads past your mark, the infection is advancing and you need to be seen immediately.

Medical References

  1. Infectious Diseases Society of America (IDSA) — Skin & Soft Tissue Infection Guidelines (2014). Standard clinical guidelines for diagnosis and treatment of cellulitis, impetigo, and skin infections.
  2. UpToDate — Cellulitis and Acute Bacterial Skin Infections (2024). Evidence-based approach to treatment and management strategies.
  3. American Academy of Family Physicians (AAFP) — Cellulitis: Recognition and Management (2023). Patient-focused guidance on skin infection management for primary care providers.
  4. CDC — Impetigo (2024). Centers for Disease Control and Prevention. Information on diagnosis, treatment, and prevention of impetigo.

Have Questions About Your Skin Infection?

If something doesn't feel right or the infection isn't improving, text us. We actually read and respond to messages.

Text Chris — Get Answers
— Chris Woods, MSN, APRN, FNP-C

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Chris Woods, NP
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